Myasthenia gravis
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Cited by (112)
The Integrated Genomic Landscape of Thymic Epithelial Tumors
2018, Cancer CellCitation Excerpt :With the observed overexpression of autoantigens in neoplastic thymic epithelial cells, defective negative T cell selection as the sole autoimmunizing mechanism is unlikely. In the absence of enrichment of any immunological signature or evidence of lymphocyte activation in MG+ thymomas, it appears more likely that “false-positive selection” driven by MHC-bound, autoantigen-derived peptides is operative or prevailing in MG+ thymomas to explain the focused anti-muscle autoimmunity in TAMG (Willcox, 1993). As mentioned previously, the mutational burden in TETs is low, except for some TC samples.
Uncommon Thoracic Tumors
2015, Clinical Radiation OncologyHereditary and Autoimmune Myasthenias
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsCD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis
2012, Journal of NeuroimmunologyThe association of HLA-DQA1*0401 and DQB1*0604 with thymomatous myasthenia gravis in northern Chinese patients
2012, Journal of the Neurological SciencesCitation Excerpt :In this heterogeneous disease it is possible to divide the patients into different subgroups depending on age of onset, clinical features, thymic histology, HLA associations [2,3], and the presence of either anti-AChR, or anti-MuSK antibodies [4]. The general consensus is that both genetic and environmental components play important roles in pathogenesis [5,6]. The known HLA associations with B8,A1, DR3 and DQ2 antigens in early-onset MG [7,8] differs in various populations, whereas Niks et al. [9] describe a strong association of MuSK antibody positive MG and HLA DR14-DQ5 in Caucasians.
Uncommon Thoracic Tumors
2012, Clinical Radiation Oncology: Third Edition