Elsevier

The Lancet

Volume 359, Issue 9323, 15 June 2002, Pages 2085-2086
The Lancet

Research Letters
Small fibre neuropathy in sarcoidosis

https://doi.org/10.1016/S0140-6736(02)08912-2Get rights and content

Summary

Some patients with sarcoidosis have unexplained pain and dysaesthesia. We did quantitative sensory testing in 31 sarcoidosis patients with pain or autonomic dysfunction. 25 patients had reduced warmth sensitivity, cold sensitivity, or both. Intraepidermal nerve fibre density (IENFD) was measured in punch biopsy skin samples in seven consecutive patients. All seven patients had reduced IENFD compared with controls, which confirmed the presence of small fibre neuropathy in these patients. Some patients with sarcoidosis may have small fibre neuropathy with autonomic involvement.

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