Elsevier

Neurologic Clinics

Volume 24, Issue 1, February 2006, Pages 123-132
Neurologic Clinics

Movement Disorders after Resuscitation from Cardiac Arrest

https://doi.org/10.1016/j.ncl.2005.11.001Get rights and content

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Posthypoxic myoclonus

Myoclonus refers to sudden, shock-like, involuntary movements that can manifest in various patterns. Myoclonus may be focal, where a few adjacent muscles are involved; multifocal, where many muscles jerk asynchronously; or generalized, where most of the muscles of the body are involved in synchronized fashion. Additionally, myoclonic movements may be spontaneous or they may be activated by either movement or sensory stimulation. Finally, myoclonus may be comprised of “positive” movements, in

Other posthypoxic movement disorders

A variety of other movement disorders are observed after cerebral hypoxia, including parkinsonism, dystonia, chorea, athetosis, and tremor [1], [2], [3], [4], [5]. Although PHM may result from injury to the cerebellum or thalamus, many of these other movement disorders are caused by damage of the basal ganglia. Dystonia is one of the more common movement disorders to occur after cerebral hypoxia and may develop in combination with an akinetic-rigid (parkinsonian) syndrome. This article

Summary

It is difficult to predict precisely the final neurologic outcome from cardiac arrest and accompanying cerebral hypoxia. Although rare, several movement disorders may arise as a consequence of hypoxic injury, including myoclonus, dystonia, akinetic-rigid syndromes, tremor, and chorea. Dysfunction of various portions of the central nervous system, including the basal ganglia, thalamus, midbrain, and cerebellum, is implicated in the pathogenesis of these posthypoxic movement disorders. The

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References (36)

  • L.L. Lim et al.

    Limited efficacy of levetiracetam on myoclonus of different etiologies

    Park Rel Dis

    (2005)
  • S. Fahn

    Posthypoxic action myoclonus: literature review update

    Adv Neurol

    (1986)
  • K. Hawker et al.

    Hypoxic-ischemic damage of the basal ganglia. Case reports and a review of the literature

    Mov Disord

    (1990)
  • A.P. Feve et al.

    Axial motor disturbances after hypoxic lesions of the globus pallidus

    Mov Disord

    (1993)
  • K.P. Bhatia et al.

    The behavioral and motor consequences of focal lesions of the basal ganglia in man

    Brain

    (1994)
  • A. Govaerts et al.

    Posthypoxic midbrain tremor

    Mov Disord

    (1998)
  • S. Fahn et al.

    Definition and classification of myoclonus

    Adv Neurol

    (1986)
  • M. Hallett

    Physiology of human posthypoxic myoclonus

    Mov Disord

    (2000)
  • J.W. Lance et al.

    The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy

    Brain

    (1963)
  • K.J. Werhahn et al.

    The clinical features and prognosis of chronic posthypoxic myoclonus

    Mov Disord

    (1997)
  • S. Frucht et al.

    The clinical spectrum of posthypoxic myoclonus

    Mov Disord

    (2000)
  • S.J. Frucht

    The clinical challenge of posthypoxic myoclonus

    Adv Neurol

    (2002)
  • E.F.M. Wijdicks et al.

    Prognostic value of myoclonus status in comatose survivors of cardiac arrest

    Ann Neurol

    (1994)
  • A.C.F. Hui et al.

    Prognosis following postanoxic myoclonus status epilepticus

    Eur Neurol

    (2005)
  • G.B. Young et al.

    The significance of myoclonic status epilepticus in postanoxic coma

    Neurology

    (1990)
  • S. Fahn

    Posthypoxic action myoclonus: review of the literature and report of two new cases with response to valproate and estrogen

    Adv Neurol

    (1979)
  • M.H.V. Woert et al.

    L-5-hydroxytryptophan therapy in myoclonus

    Adv Neurol

    (1979)
  • D.D. Truong et al.

    Novel rat cardiac arrest model of posthypoxic moclonus

    Mov Disord

    (1994)
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