Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration
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Intravenous transplantation of bone marrow-derived mesenchymal stromal cells in patients with multiple sclerosis, a phase I/IIa, double blind, randomized controlled study
2023, Multiple Sclerosis and Related DisordersNew idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders: Combining with intranasal delivery
2022, Acta Pharmaceutica Sinica BCitation Excerpt :The flexible treatment regimens provided by the non-invasive IN route also could solve problems in invasiveness and regimen of stem cells or EVs-based therapy. As we discussed above, IN route showed many advantages over current used administration route: the IV route has a poor lesion site transplantation rate69‒71; the topical injection is highly invasive and the frequency of dosage in topical injection was constrained77,145,160; other administration routes like intra-arterial (IA) or intraperitoneal injection (IP) also fail to realize high CNS delivery efficiency, and both are relatively invasive161,162. On the contrary, IN route could provide a direct nose-to-brain delivery and a high brain graft rate for stem cells or EVs.
Mesenchymal stem cells in experimental autoimmune encephalomyelitis model of multiple sclerosis: A systematic review and meta-analysis
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