Neuron
Volume 72, Issue 2, 20 October 2011, Pages 385-396
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Article
Lichtheim 2: Synthesizing Aphasia and the Neural Basis of Language in a Neurocomputational Model of the Dual Dorsal-Ventral Language Pathways

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Summary

Traditional neurological models of language were based on a single neural pathway (the dorsal pathway underpinned by the arcuate fasciculus). Contemporary neuroscience indicates that anterior temporal regions and the “ventral” language pathway also make a significant contribution, yet there is no computationally-implemented model of the dual pathway, nor any synthesis of normal and aphasic behavior. The “Lichtheim 2” model was implemented by developing a new variety of computational model which reproduces and explains normal and patient data but also incorporates neuroanatomical information into its architecture. By bridging the “mind-brain” gap in this way, the resultant “neurocomputational” model provides a unique opportunity to explore the relationship between lesion location and behavioral deficits, and to provide a platform for simulating functional neuroimaging data.

Highlights

► A computational implementation of the classic Lichtheim language model ► Incorporation of ventral and dorsal “pathways” into the language model ► A formal simulation of classic and progressive types of aphasia ► Incorporation of neuroanatomical constraints into computational architecture

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