CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?

J Neuroimmunol. 2003 Mar;136(1-2):149-53. doi: 10.1016/s0165-5728(03)00012-2.

Abstract

Previous investigations have suggested that Sydenham's chorea (SC) may be an autoantibody mediated disorder. We examined this autoimmune hypothesis by measuring Th1 (IFN-gamma, IL-12) and Th2 (IL-4, IL-10) cytokines, oligoclonal bands (OCB) and anti-basal ganglia antibodies (ABGA). CSF IL-4 was elevated in 31% of acute SC and 50% of persistent SC. CSF IL-10 was also elevated in 31% of acute SC but 0% of persistent SC. CSF IFN-gamma was undetectable in all patients. Serums IL-4, IL-10 and IL-12 were elevated in acute compared to persistent SC. OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / blood*
  • Autoantibodies / cerebrospinal fluid*
  • Autoimmune Diseases of the Nervous System / blood
  • Autoimmune Diseases of the Nervous System / cerebrospinal fluid
  • Autoimmune Diseases of the Nervous System / immunology*
  • Basal Ganglia / immunology*
  • Basal Ganglia / pathology
  • Basal Ganglia / physiopathology
  • Child
  • Child, Preschool
  • Chorea / blood
  • Chorea / cerebrospinal fluid
  • Chorea / immunology*
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid
  • Immunoglobulins / blood
  • Immunoglobulins / cerebrospinal fluid
  • Immunoglobulins / immunology
  • Interleukins / blood*
  • Interleukins / cerebrospinal fluid*
  • Male
  • Oligoclonal Bands
  • Th1 Cells / immunology
  • Th2 Cells / immunology

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulins
  • Interleukins
  • Oligoclonal Bands