Advances in the hereditary spastic paraplegias

Exp Neurol. 2003 Nov:184 Suppl 1:S106-10. doi: 10.1016/j.expneurol.2003.08.005.

Abstract

This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes have been discovered. This progress has yielded new insights into the diverse molecular pathogenesis that underlies these clinically similar disorders.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • Genes, Dominant
  • Genetic Linkage
  • Humans
  • Lower Extremity
  • Sex Chromosome Aberrations
  • Spastic Paraplegia, Hereditary* / classification
  • Spastic Paraplegia, Hereditary* / diagnosis
  • Spastic Paraplegia, Hereditary* / genetics
  • Spastic Paraplegia, Hereditary* / pathology
  • Therapeutics
  • Walking