Demyelinating polyneuropathy in Leber hereditary optic neuropathy

H J Gilhuis; H J Schelhaas; J R M Cruysberg; M J Zwarts

doi:10.1016/j.nmd.2006.03.006

Demyelinating polyneuropathy in Leber hereditary optic neuropathy

Neuromuscul Disord. 2006 Jun;16(6):394-5. doi: 10.1016/j.nmd.2006.03.006. Epub 2006 May 11.

Authors

H J Gilhuis¹, H J Schelhaas, J R M Cruysberg, M J Zwarts

Affiliation

¹ Department of Neurology and Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. gilhuis@rdgg.nl

PMID: 16690316
DOI: 10.1016/j.nmd.2006.03.006

Abstract

We report a patient with Leber hereditary optic neuropathy (G11778A mtDNA) and a severe demyelinating neuropathy, for which no other cause except his mitochondrial disorder could be found. The involvement of the peripheral nervous system of patients with LHON, in particular with a 11778 mtDNA, is discussed.

Publication types

Case Reports

MeSH terms

DNA, Mitochondrial / genetics
Demyelinating Diseases / pathology
Humans
Male
Middle Aged
Optic Atrophy, Hereditary, Leber / complications*
Optic Atrophy, Hereditary, Leber / diagnosis
Optic Atrophy, Hereditary, Leber / genetics
Optic Atrophy, Hereditary, Leber / pathology
Polyneuropathies / diagnosis
Polyneuropathies / etiology*
Polyneuropathies / genetics
Polyneuropathies / pathology

Substances

DNA, Mitochondrial