National General Practice Study of Epilepsy: recurrence after a first seizure

Lancet. 1990 Nov 24;336(8726):1271-4. doi: 10.1016/0140-6736(90)92960-p.

Abstract

In the National General Practice Study of Epilepsy 564 patients classified as having definite seizures have been followed up for 2-4 years. 67% (95% confidence interval 63-71%) had a recurrence within 12 months of the first seizure, and 78% (74-81%) had a recurrence within 36 months. Seizures associated with a neurological deficit presumed present at birth had a high rate of recurrence (100% by 12 months), whereas seizures that occurred within 3 months of an acute insult to the brain, such as head injury or stroke, or in the context of an acute precipitant such as alcohol, carried a much lower risk of recurrence (40% [29-51%] by 12 months). Other factors affecting the risk of recurrence were age-the highest risk being for patients under the age of 16 (83% [77-89%] by 36 months) or over the age of 59 (83% [76-90%] by 36 months-and type of first seizure-the risk of recurrence being much higher for patients with simple partial or complex partial seizures (94% [90-99%] by 36 months) than for those with generalised tonic clonic seizures (72% [67-77%] by 36 months).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actuarial Analysis
  • Adolescent
  • Adult
  • Age Factors
  • Bias
  • Child
  • Child, Preschool
  • Epilepsy / classification
  • Epilepsy / epidemiology*
  • Epilepsy / etiology
  • Evaluation Studies as Topic
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • National Health Programs*
  • Prognosis
  • Recurrence
  • Risk Factors
  • Time Factors
  • United Kingdom / epidemiology