Abstract
Neurosarcoidosis can worsen despite standard immunosuppressive therapy, a situation for which there is no established medical management. We present three cases of medically refractory neurosarcoidosis treated with infliximab. All three patients showed a clinical response to this treatment and side effects were limited. A summary of reported cases of neurosarcoidosis treated with infliximab is included. This case series supports a role for infliximab in the treatment of patients with medically refractory neurosarcoidosis.
© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.
MeSH terms
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Adult
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Antibodies, Monoclonal / administration & dosage*
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Central Nervous System Diseases / diagnosis*
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Central Nervous System Diseases / drug therapy*
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Central Nervous System Diseases / immunology
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Drug Administration Schedule
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Drug Resistance / drug effects
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Drug Resistance / immunology
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Female
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Follow-Up Studies
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Humans
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Immunosuppressive Agents / administration & dosage
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Infliximab
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Male
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Sarcoidosis / diagnosis*
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Sarcoidosis / drug therapy*
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Sarcoidosis / immunology
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Treatment Outcome
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Tumor Necrosis Factor-alpha* / immunology
Substances
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Antibodies, Monoclonal
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Immunosuppressive Agents
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Tumor Necrosis Factor-alpha
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Infliximab