BACKGROUND AND OBJECTIVE: Hypoxic-ischemic encephalopathy (HIE) after perinatal
asphyxia in term neonates causes long-term neurologic sequelae or death. A reliable …

Background Disorders of posture, gait, and balance in Parkinson's disease (PD) are
common and debilitating. This MDS‐commissioned task force assessed clinimetric …

The purpose of this systematic review is to summarize studies that describe the course of
Parkinson's disease (PD) and to identify factors that predict change in motor impairment …

Objective: To determine the frequency and pattern of cognitive dysfunction in patients with
newly diagnosed Parkinson disease (PD) and to identify its demographic and clinical …

Background Iron content is increased in the substantia nigra of persons with Parkinson's
disease and may contribute to the pathophysiology of the disorder. Early research suggests …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

Objective: To identify factors that independently contribute to disability and quality of life
(QoL) in patients with mild to moderate Parkinson disease (PD). Methods: A group of 190 …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Background High-intensity aerobic exercise might attenuate the symptoms of Parkinson's
disease, but high-quality evidence is scarce. Moreover, long-term adherence remains …

Background Levodopa is the main treatment for symptoms of Parkinson's disease.
Determining whether levodopa also has a disease-modifying effect could provide guidance …