Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Background Up to date data on incidence, mortality, and case-fatality for stroke are important
for setting the agenda for prevention and healthcare. Aims and/or hypothesis We aim to …

Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Background In 2015, five randomised trials showed efficacy of endovascular thrombectomy
over standard medical care in patients with acute ischaemic stroke caused by occlusion of …

Background Trials of endovascular therapy for ischemic stroke have produced variable
results. We conducted this study to test whether more advanced imaging selection, recently …

Importance Endovascular thrombectomy with second-generation devices is beneficial for
patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the …

Background Early administration of intravenous recombinant tissue plasminogen activator (rt-
PA) after ischaemic stroke improves outcome. Previous analysis of combined data from …

Background Whether intravenous tissue plasminogen activator (alteplase) is effective
beyond 3 h after onset of acute ischaemic stroke is unclear. We aimed to test whether …

Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study
compared the efficacy and safety of two antiplatelet regimens—aspirin plus extended …

Objective Preclinical evaluation of neuroprotectants fostered high expectations of clinical
efficacy. When not matched, the question arises whether experiments are poor indicators of …