Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to
involve only the optic nerves and spinal cord. However, the discovery of highly specific anti …

Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in
patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis …

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently
identified autoimmune disorder that presents in both adults and children as CNS …

Although recent animal studies have fuelled growing interest in Ab-independent functions of
B cells, relatively little is known about how human B cells and their subsets may contribute to …

Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune,
inflammatory disorder that typically affects the optic nerves and spinal cord. At least two …

Background No approved therapies exist for neuromyelitis optica spectrum disorder
(NMOSD), a rare, relapsing, autoimmune, inflammatory disease of the CNS that causes …

Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis where one of their
roles may be to facilitate the transmigration of circulating leukocytes into the CNS. Studies …

Importance A previous 2-year analysis of repeated rituximab treatment in patients with
neuromyelitis optica (NMO) revealed significant improvements in relapse rates and …

Objective To evaluate the efficacy and safety of repeated rituximab treatment based on the
assessment of peripheral circulating memory B cells over 24 months in patients with …

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous
system that preferentially targets the optic nerves and spinal cord. The clinical presentation …