The extent of microglial heterogeneity in humans remains a central yet poorly explored
question in light of the development of therapies targeting this cell type. Here, we investigate …

Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs
primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms …

Introduction We describe the imaging findings encountered in GBM patients receiving
immune checkpoint blockade and assess the potential of quantitative MRI biomarkers to …

Background KIAA1549-BRAF fusion is the most common genetic event in pilocytic
astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) …

Importance Powassan virus is a rare but increasingly recognized cause of severe
neurological disease. Objective To highlight the diagnostic challenges and …

The neurotrophin receptor, TrkB receptor tyrosine kinase, is critical to central nervous system
(CNS) function in health and disease. Elucidating the ligands mediating TrkB activation in …

Recent studies of bulk microglia have provided insights into the role of this immune cell type
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …

Spinal hemangiomas are common, benign vascular lesions that involve the bony portion of
vertebral bodies and are generally asymptomatic. Rarely, they can become aggressive and …

Purpose: To establish bedside biomarkers of myosteatosis for sarcopenia and cachexia. We
compared ultrasound biomarkers against MRI-based percent fat, histology, and CT-based …

Understanding the mechanisms of limbic epileptogenesis in cellular and molecular terms
may provide novel therapeutic targets for its prevention. The neurotrophin receptor …