This article provides a classification of primary progressive aphasia (PPA) and its 3 main
variants to improve the uniformity of case reporting and the reliability of research results …

Frontotemporal dementia (FTD) is the second most common young-onset dementia and is
clinically characterised by progressive behavioural change, executive dysfunction and …

This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Based on the recent literature and collective experience, an international consortium
developed revised guidelines for the diagnosis of behavioural variant frontotemporal …

Background We aimed to accurately estimate the frequency of a hexanucleotide repeat
expansion in C9orf72 that has been associated with a large proportion of cases of …

To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD)
from normal aging in individual scans. Recent advances in statistical learning theory have …

Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as a
major cause of familial frontotemporal lobar degeneration and motor neuron disease …

Objective: To investigate serum neurofilament light chain (NfL) concentrations in
frontotemporal dementia (FTD) and to see whether they are associated with the severity of …