Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a
poor prognosis and limited treatment options. Diagnosis is often challenging, with …

Autophosphorylating histidine kinases are an ancient conserved family of enzymes that are
found in eubacteria, archaebacteria and eukaryotes. They are activated by a wide range of …

Anti-angiogenic therapy has become an important component in the treatment of many solid
tumors given the importance of adequate blood supply for tumor growth and metastasis …

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

Abstract The C ovid-19 Open Research Dataset (CORD-19) is a growing 1 resource of
scientific papers on C ovid-19 and related historical coronavirus research. CORD-19 is …

The survival motor neuron gene is present in humans in a telomeric copy, SMN1, and
several centromeric copies, SMN2. Homozygous mutation of SMN1 is associated with …

Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by
degeneration of the anterior horn cells of the spinal cord, leading to muscular paralysis with …

Companies have recently begun to sell a new service to patients considering in vitro
fertilization: embryo selection based on polygenic scores (ESPS). These scores represent …

RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells
that directs the degradation of messenger RNAs homologous to short double-stranded …

Optogenetics with microbial opsin genes has enabled high-speed control of genetically
specified cell populations in intact tissue. However, it remains a challenge to independently …