Strokes: mimics and chameleons

PM Fernandes, WN Whiteley, SR Hart… - Practical neurology, 2013 - pn.bmj.com
Diagnosing stroke is not always straightforward. Stroke mimics such as Todd's paresis or
hemiplegic migraine account for between a fifth and a quarter of suspected strokes …

How to do it: investigate exertional rhabdomyolysis (or not)

PM Fernandes, RJ Davenport - Practical Neurology, 2019 - pn.bmj.com
Rhabdomyolysis is the combination of symptoms (myalgia, weakness and muscle swelling)
and a substantial rise in serum creatine kinase (CK)> 50 000 IU/L; there are many causes …

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

PM Fernandes, J Kinkead, I McNae… - Biochemical …, 2020 - portlandpress.com
6-Phosphofructokinase-1-kinase (PFK) tetramers catalyse the phosphorylation of fructose 6-
phosphate (F6P) to fructose 1, 6-bisphosphate (F16BP). Vertebrates have three PFK …

[HTML][HTML] Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

IW McNae, J Kinkead, D Malik, LH Yen… - Nature …, 2021 - nature.com
The parasitic protist Trypanosoma brucei is the causative agent of Human African
Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the …

[HTML][HTML] Guillain-Barré syndrome following SARS-CoV-2 vaccination in the UK: a prospective surveillance study

AA Tamborska, B Singh, SE Leonhard… - BMJ neurology …, 2022 - ncbi.nlm.nih.gov
Objective To investigate features of Guillain-Barré syndrome (GBS) following SARS-CoV-2
vaccines and evaluate for a causal link between the two. Methods We captured cases of …

[HTML][HTML] Impact of the first COVID-19 pandemic wave on the Scottish Multiple Sclerosis Register population

PM Fernandes, M O'neill, PKA Kearns… - Wellcome Open …, 2020 - ncbi.nlm.nih.gov
Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on people
with multiple sclerosis (MS) is a major current concern, in particular the risk of death. Here …

Characterization of glucose oxidase immobilized on collagen

A Constantinides, WR Vieth, PM Fernandes - Molecular and Cellular …, 1973 - Springer
The enzyme glucose oxidase (EC 1.1. 3.4) was immobilized on collagen—a proteinaceous
material found in biological systems as a structural material for a wide variety of cells and …

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

PM Fernandes, J Kinkead, IW McNae… - Biochemical …, 2019 - portlandpress.com
Eukaryotic ATP-dependent phosphofructokinases (PFKs) are often considered
unidirectional enzymes catalysing the transfer of a phospho moiety from ATP to fructose 6 …

Preparation of a stable intravenous gamma‐globulin: process design and scale‐up

PM Fernandes, JL Lundblad - Vox Sanguinis, 1980 - Wiley Online Library
Intravenous γ‐globulin has been prepared on a pilot scale by the process of reduction with
dithiothreitol and alkylation with iodoacetamide. The spent reagents are removed by …

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis …

PM Fernandes, J Kinkead, IW McNae… - The FEBS …, 2020 - Wiley Online Library
Trypanosomatids possess glycosome organelles that contain much of the glycolytic
machinery, including phosphofructokinase (PFK). We present kinetic and structural data for …