User profiles for "author:Simon Mead"

Simon Mead

Deputy Director MRC Prion Unit at UCL; CJD specialist UCLH; NIHR Senior Investigator
Verified email at prion.ucl.ac.uk
Cited by 42860

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

[HTML][HTML] Prion disease genetics

S Mead - European Journal of Human Genetics, 2006 - nature.com
Prion diseases have stimulated intense scientific scrutiny since it was proposed that the
infectious agent was devoid of nucleic acid. Despite this finding, genetics has played a key …

Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease

P Hermann, B Appleby, JP Brandel, B Caughey… - The Lancet …, 2021 - thelancet.com
Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj… - Nature …, 2013 - nature.com
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

D Harold, R Abraham, P Hollingworth, R Sims… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

P Hollingworth, D Harold, R Sims, A Gerrish… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

[HTML][HTML] Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

E Majounie, AE Renton, K Mok, EGP Dopper… - The Lancet …, 2012 - thelancet.com
Background We aimed to accurately estimate the frequency of a hexanucleotide repeat
expansion in C9orf72 that has been associated with a large proportion of cases of …

Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics

S Mead, MPH Stumpf, J Whitfield, JA Beck, M Poulter… - Science, 2003 - science.org
Kuru is an acquired prion disease largely restricted to the Fore linguistic group of the Papua
New Guinea Highlands, which was transmitted during endocannibalistic feasts …

[HTML][HTML] Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

L Jones, PA Holmans, ML Hamshere, D Harold… - PloS one, 2010 - journals.plos.org
Background Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia.
Recent large genome-wide association studies (GWAS) identified the first strongly …

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Z Jaunmuktane, S Mead, M Ellis, JDF Wadsworth… - Nature, 2015 - nature.com
More than two hundred individuals developed Creutzfeldt–Jakob disease (CJD) worldwide
as a result of treatment, typically in childhood, with human cadaveric pituitary-derived growth …