Diagnosis of multiple sclerosis: progress and challenges

WJ Brownlee, TA Hardy, F Fazekas, DH Miller - The Lancet, 2017 - thelancet.com
The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …

Clinically isolated syndromes and the relationship to multiple sclerosis

WJ Brownlee, DH Miller - Journal of Clinical Neuroscience, 2014 - Elsevier
The most common presentation of multiple sclerosis (MS) is with a clinically isolated
syndrome (CIS) affecting the optic nerves, brainstem or spinal cord. Two thirds of patients …

Differential diagnosis of suspected multiple sclerosis: an updated consensus approach

AJ Solomon, G Arrambide, WJ Brownlee… - The Lancet …, 2023 - thelancet.com
Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis—
many disorders can mimic the clinical manifestations and paraclinical findings of this …

Deep gray matter volume loss drives disability worsening in multiple sclerosis

A Eshaghi, F Prados, WJ Brownlee… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Progression of regional grey matter atrophy in multiple sclerosis

A Eshaghi, RV Marinescu, AL Young, NC Firth… - Brain, 2018 - academic.oup.com
Abstract See Stankoff and Louapre (doi: 10.1093/brain/awy114) for a scientific commentary
on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis …

Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis

WJ Brownlee, DR Altmann, F Prados, KA Miszkiel… - Brain, 2019 - academic.oup.com
The clinical course of relapse-onset multiple sclerosis is highly variable. Demographic
factors, clinical features and global brain T2 lesion load have limited value in counselling …

Longitudinal assessment of multiple sclerosis with the brain‐age paradigm

JH Cole, J Raffel, T Friede, A Eshaghi… - Annals of …, 2020 - Wiley Online Library
Objective During the natural course of multiple sclerosis (MS), the brain is exposed to aging
as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain …

Incidence and prevalence of NMOSD in Australia and New Zealand

W Bukhari, KM Prain, P Waters, M Woodhall… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objectives We have undertaken a clinic-based survey of neuromyelitis optica spectrum
disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence …

Disease-modifying therapies for multiple sclerosis

F De Angelis, NA John, WJ Brownlee - bmj, 2018 - bmj.com
1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute
of Neurology, London, UK; 2National Hospital for Neurology and Neurosurgery, Queen …

Earlier and more frequent diagnosis of multiple sclerosis using the McDonald criteria

WJ Brownlee, JK Swanton, DR Altmann… - Journal of Neurology …, 2015 - jnnp.bmj.com
The McDonald criteria allow multiple sclerosis (MS) to be diagnosed in patients with a
clinically isolated syndrome (CIS) who have MRI evidence of dissemination in time and …