Diagnosis of multiple sclerosis: progress and challenges
The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …
Clinically isolated syndromes and the relationship to multiple sclerosis
WJ Brownlee, DH Miller - Journal of Clinical Neuroscience, 2014 - Elsevier
The most common presentation of multiple sclerosis (MS) is with a clinically isolated
syndrome (CIS) affecting the optic nerves, brainstem or spinal cord. Two thirds of patients …
syndrome (CIS) affecting the optic nerves, brainstem or spinal cord. Two thirds of patients …
Differential diagnosis of suspected multiple sclerosis: an updated consensus approach
AJ Solomon, G Arrambide, WJ Brownlee… - The Lancet …, 2023 - thelancet.com
Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis—
many disorders can mimic the clinical manifestations and paraclinical findings of this …
many disorders can mimic the clinical manifestations and paraclinical findings of this …
Deep gray matter volume loss drives disability worsening in multiple sclerosis
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …
Progression of regional grey matter atrophy in multiple sclerosis
Abstract See Stankoff and Louapre (doi: 10.1093/brain/awy114) for a scientific commentary
on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis …
on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis …
Early imaging predictors of long-term outcomes in relapse-onset multiple sclerosis
WJ Brownlee, DR Altmann, F Prados, KA Miszkiel… - Brain, 2019 - academic.oup.com
The clinical course of relapse-onset multiple sclerosis is highly variable. Demographic
factors, clinical features and global brain T2 lesion load have limited value in counselling …
factors, clinical features and global brain T2 lesion load have limited value in counselling …
Longitudinal assessment of multiple sclerosis with the brain‐age paradigm
Objective During the natural course of multiple sclerosis (MS), the brain is exposed to aging
as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain …
as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain …
Incidence and prevalence of NMOSD in Australia and New Zealand
W Bukhari, KM Prain, P Waters, M Woodhall… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objectives We have undertaken a clinic-based survey of neuromyelitis optica spectrum
disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence …
disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence …
Disease-modifying therapies for multiple sclerosis
F De Angelis, NA John, WJ Brownlee - bmj, 2018 - bmj.com
1Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute
of Neurology, London, UK; 2National Hospital for Neurology and Neurosurgery, Queen …
of Neurology, London, UK; 2National Hospital for Neurology and Neurosurgery, Queen …
Earlier and more frequent diagnosis of multiple sclerosis using the McDonald criteria
WJ Brownlee, JK Swanton, DR Altmann… - Journal of Neurology …, 2015 - jnnp.bmj.com
The McDonald criteria allow multiple sclerosis (MS) to be diagnosed in patients with a
clinically isolated syndrome (CIS) who have MRI evidence of dissemination in time and …
clinically isolated syndrome (CIS) who have MRI evidence of dissemination in time and …