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Conus medullaris syndrome as a presenting feature of MOG-associated disease
  1. Memoona Nasir,
  2. Ruth Obrocki,
  3. Magdalini Krommyda,
  4. Naveed Malek
  1. Queen's Hospital Department of Neurology, Romford, UK
  1. Correspondence to Dr Memoona Nasir, Queen's Hospital Department of Neurology, Romford, London, UK; memoona.nasir{at}nhs.net

Abstract

We report a case of conus medullaris syndrome presenting with lower limb and bladder symptoms. MR imaging showed an abnormality in the lowest part of the spinal cord as a first presentation of myelin oligodendrocyte glycoprotein (MOG)-associated disease. While such cord swelling can mimic a tumour, these patients respond well to corticosteroids, with good outcomes. MOG-associated disease is an immune-mediated syndrome distinct from aquaporin 4 antibody positive neuromyelitis optica syndrome and is now considered an independent entity. Although there can be overlapping phenotypes, there are also differences, and MOG-associated disease generally has a much better prognosis compared with aquaporin 4 antibody-positive neuromyelitis optica syndrome.

  • MYELOPATHY

Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information. Not Applicable.

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Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information. Not Applicable.

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Footnotes

  • Twitter @ruthclamb

  • Contributors Al authors contributed equally.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed by Emma Tallantyre, Cardiff, UK.

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