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Looking out for the blind spot
  1. Viswas Dayal1,
  2. Vivien Teh1,
  3. David McAuley1,
  4. Stephen Reddel2,
  5. Richard Roxburgh1
  1. 1Department of Neurology, Auckland City Hospital, Auckland, New Zealand
  2. 2Department of Neurology, Brain and Mind Research Institute, Sydney, New South Wales, Australia
  1. Correspondence to Dr Viswas Dayal, Department of Neurology, Auckland City Hospital, 2 Park Road, Grafton, Auckland 1023, New Zealand; vdayal{at}

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The case

A 49-year-old woman presented in July 2014 with a 1-week history of confusion, particularly with memory and word-finding difficulties. She also gave a 3-month history of reduced hearing, initially acutely in the right ear, and a 2-day history of vertigo and vomiting. The vertigo resolved but over the next month she noticed hearing loss affecting the left side as well. Her husband reported that she had had an episode of disorientation and confusion 2 months earlier; this had only lasted a day but her cognition had been completely normal since. She had no vascular risk factors, past medical history or history of using any recreational drug.

On examination, she was afebrile and normotensive but was disorientated to day and date. Visual acuity and fundoscopy were normal. Eye movements were normal, as were the other cranial nerves, apart from bilateral hearing loss. The head impulse test was negative. There was mild impairment of rapid alternating movements in the right arm and difficulty with tandem gait.

The Montreal cognitive assessment test gave a score of 18/30. A delirium screen with blood tests, including a full blood count, electrolytes, liver function tests, C reactive protein and erythrocyte sedimentation rate, was normal. A chest radiograph, urine and blood cultures were negative. A CT scan of head was normal but an MRI scan of brain was floridly abnormal (figure 1).

Figure 1

MRI scan of brain (July). Images showing axial T2 (A and B); sagittal fluid-attenuated inversion recovery (C); coronal T2 (D); diffusion-weighted imaging (DWI) (E); sagittal postcontrast T1 (F).

Question 1

What are your differential diagnoses and what further investigations would you request?

The MRI scan of brain shows multiple areas of high T2 and fluid-attenuated inversion recovery (FLAIR) signal within the cerebrum, corpus callosum, cerebellum and brainstem.

Acute disseminated encephalomyelitis (ADEM) was our primary differential diagnosis. There …

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  • Contributors VD wrote the draft paper including questions and discussion and reviewed the existing literature. VT summarised the clinical case and obtained radiological images. SR revised the draft paper and provided specialist expertise on discussion of the condition. DM revised and proofread the draft paper. RR revised the draft paper and did the final review.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Commissioned; externally peer-reviewed. This paper was reviewed by Alasdair Coles, Cambridge, UK.

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  • Editors' commentary
    Phil Smith Geraint N Fuller

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